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dynasore (dynamin inhibitor i)  (Millipore)


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    Millipore dynasore (dynamin inhibitor i)
    Dynasore (Dynamin Inhibitor I), supplied by Millipore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dynasore+(dynamin+inhibitor+i)/dynamin+inhibitor+dynasore/pm39596012-167-36-40
    Average 90 stars, based on 1 article reviews
    dynasore (dynamin inhibitor i) - by Bioz Stars, 2026-10
    90/100 stars

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    other:

    Article Title: Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells
    Article Snippet: In addi- tion to desmopressin, in specific experiments for the final 24 hours the cells were treated with tolvaptan (10 nM) (Sigma-Aldrich), endothelin-1 (10 pM) (Sigma-Aldrich), or H-89 (25 mM) (Sigma-Aldrich).26 Treatment with the Dynamin Inhibitor I (Dynasore 150 mM, Sigma-Aldrich) was for 45 minutes immediately before addition, as per published studies.21 Cells were treated with 10mM forskolin from Coleus forskohlii (Sigma-Aldrich) and incubated with fluorescent ECVs overnight.27,28 To polarize the mCCDC11 cells, they were cultured on the polyester membrane of Transwell inserts (Corning Costar Co.) at a high density to allow the cells to be confluent within 3 days.

    Article Title: Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells
    Article Snippet: 26 Treatment with the Dynamin Inhibitor I (Dynasore 150 μ M, Sigma-Aldrich) was for 45 minutes immediately before addition, as per published studies.

    Article Title: Distribution and Incorporation of Extracellular Vesicles into Chondrocytes and Synoviocytes.
    Article Snippet: Additional reagents used included PKH67 Fluorescent Cell Linker Kits (SigmaAldrich, Saint Louis, MO, USA), ExoSparkler EVs Membrane Labelling Kit-Red (EX02, Dojindo, Japan), the Cell Navigator F-Actin Labelling Kit (Green Fluorescence) (AAT Bioquest, Pleasanton, CA, USA) and dynasore (dynamin inhibitor I) (Calbiochem, Gibbstown, NJ, USA).

    Article Title: Distribution and Incorporation of Extracellular Vesicles into Chondrocytes and Synoviocytes
    Article Snippet: Additional reagents used included PKH67 Fluorescent Cell Linker Kits (Sigma-Aldrich, Saint Louis, MO, USA), ExoSparkler EVs Membrane Labelling Kit-Red (EX02, Dojindo, Japan), the Cell Navigator F-Actin Labelling Kit (Green Fluorescence) (AAT Bioquest, Pleasanton, CA, USA) and dynasore (dynamin inhibitor I) (Calbiochem, Gibbstown, NJ, USA).

    Article Title: Dynamin 2-mediated endocytosis of BLT1 is required for IL-8 production in HMC-1 cells induced by Trichomonas vaginalis -derived secretory products
    Article Snippet: Dynasore (dynamin inhibitor I) was purchased from Calbiochem (Gibbstown, NJ, USA).

    Article Title: Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils.
    Article Snippet: A cc ep te d A rt ic le This article is protected by copyright.. All rights reserved The pathological hallmark of Parkinson Disease (PD) are Lewy bodies that form within the brain from aggregated forms of α-synuclein.. These toxic α-synuclein aggregates transfer from cell to cell by release of fibrils from dying neurons into the extracellular environment, followed by their subsequent uptake by neighboring cells.

    Inhibition:

    Article Title: Engineering synthetic agonists for targeted activation of Notch signaling
    Article Snippet: .. When testing inhibition of endocytosis, 80 μM of the Dynamin inhibitor I (Dynasore, Sigma) was added to the mixture of Notch reporter cells with protein and added to the tissue culture 96-well plate containing the signal-sending cells. ..



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    Figure 2. Cardiac mitochondria are internalized by MSCs through dynamin-dependent, clathrin- mediated <t>endocytosis.</t> (A) Representative confocal microscopy pictures of WGA-stained MSCs after 24 h of incubation with MitoTracker Green-labeled cardiac mitochondria at the Mito 3 concentration in the absence or presence of <t>dynasore.</t> Scale bar: 5 µm. (B) Flow cytometry quantification of Mito- Tracker Green-labeled cardiac mitochondria by MSCs following 24 h of exposure in the presence or absence of dynasore (n = 4). (C) Relative Ki67 mRNA levels in cardiac mitochondria-preconditioned MSCs in the presence or absence of dynasore in reference to their respective controls (n = 4). (D) Relative VEGF and HGF mRNA levels in cardiac mitochondria-preconditioned MSCs in the presence or absence of dynasore in reference to their respective controls (n = 4). (E) Relative mRNA levels of CXCL1, CXCL5, CXCL6, IL11, IL33 and LIF in cardiac mitochondria-preconditioned MSCs in the presence or absence of dynasore in reference to their respective controls (n = 4). (F) Relative mRNA levels of MMP1, MMP9 and MMP14 (n =4) and (G) collagenase activity (n = 10) in cardiac mitochondria-preconditioned MSCs in the presence or absence of dynasore in reference to their respective controls. One-way ANOVA with Dunn’s multiple comparisons test in (B–F). One-way ANOVA with Tukey’s multiple comparisons test in (G). * p < 0.05, ** p < 0.01, *** p < 0.001. Each dot represents an independent experiment. Bar graphs represent mean values ± SD.
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    Figure 2. Cardiac mitochondria are internalized by MSCs through dynamin-dependent, clathrin- mediated endocytosis. (A) Representative confocal microscopy pictures of WGA-stained MSCs after 24 h of incubation with MitoTracker Green-labeled cardiac mitochondria at the Mito 3 concentration in the absence or presence of dynasore. Scale bar: 5 µm. (B) Flow cytometry quantification of Mito- Tracker Green-labeled cardiac mitochondria by MSCs following 24 h of exposure in the presence or absence of dynasore (n = 4). (C) Relative Ki67 mRNA levels in cardiac mitochondria-preconditioned MSCs in the presence or absence of dynasore in reference to their respective controls (n = 4). (D) Relative VEGF and HGF mRNA levels in cardiac mitochondria-preconditioned MSCs in the presence or absence of dynasore in reference to their respective controls (n = 4). (E) Relative mRNA levels of CXCL1, CXCL5, CXCL6, IL11, IL33 and LIF in cardiac mitochondria-preconditioned MSCs in the presence or absence of dynasore in reference to their respective controls (n = 4). (F) Relative mRNA levels of MMP1, MMP9 and MMP14 (n =4) and (G) collagenase activity (n = 10) in cardiac mitochondria-preconditioned MSCs in the presence or absence of dynasore in reference to their respective controls. One-way ANOVA with Dunn’s multiple comparisons test in (B–F). One-way ANOVA with Tukey’s multiple comparisons test in (G). * p < 0.05, ** p < 0.01, *** p < 0.001. Each dot represents an independent experiment. Bar graphs represent mean values ± SD.

    Journal: Cells

    Article Title: Transfer of Cardiac Mitochondria Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in a Preclinical Model of Ischemic Heart Disease.

    doi: 10.3390/cells12040582

    Figure Lengend Snippet: Figure 2. Cardiac mitochondria are internalized by MSCs through dynamin-dependent, clathrin- mediated endocytosis. (A) Representative confocal microscopy pictures of WGA-stained MSCs after 24 h of incubation with MitoTracker Green-labeled cardiac mitochondria at the Mito 3 concentration in the absence or presence of dynasore. Scale bar: 5 µm. (B) Flow cytometry quantification of Mito- Tracker Green-labeled cardiac mitochondria by MSCs following 24 h of exposure in the presence or absence of dynasore (n = 4). (C) Relative Ki67 mRNA levels in cardiac mitochondria-preconditioned MSCs in the presence or absence of dynasore in reference to their respective controls (n = 4). (D) Relative VEGF and HGF mRNA levels in cardiac mitochondria-preconditioned MSCs in the presence or absence of dynasore in reference to their respective controls (n = 4). (E) Relative mRNA levels of CXCL1, CXCL5, CXCL6, IL11, IL33 and LIF in cardiac mitochondria-preconditioned MSCs in the presence or absence of dynasore in reference to their respective controls (n = 4). (F) Relative mRNA levels of MMP1, MMP9 and MMP14 (n =4) and (G) collagenase activity (n = 10) in cardiac mitochondria-preconditioned MSCs in the presence or absence of dynasore in reference to their respective controls. One-way ANOVA with Dunn’s multiple comparisons test in (B–F). One-way ANOVA with Tukey’s multiple comparisons test in (G). * p < 0.05, ** p < 0.01, *** p < 0.001. Each dot represents an independent experiment. Bar graphs represent mean values ± SD.

    Article Snippet: To characterize the endocytosis process by which MSCs internalize cardiac mitochondria, human MSCs were exposed to cardiac mitochondria previously labeled with MitoTracker Green FM (40 nM, Invitrogen, Waltham, MA, USA, Cat#M7514) in the presence of the dynamin-dependent, clathrin-mediated endocytosis inhibitor dynasore (50mM, Santa Cruz Biotechnology, Dallas, TX, USA, Cat#sc-202592).

    Techniques: Confocal Microscopy, Staining, Incubation, Labeling, Concentration Assay, Flow Cytometry, Activity Assay